Spinal Muscular Atrophy Write for Us
Spinal Muscular Atrophy Write for Us – The central neurological system, peripheral nervous system, and voluntary muscle movement (skeletal muscle) are all impacted by the hereditary condition known as spinal muscular atrophy (SMA).-Most nerve cells that control muscles are located in the spinal cord, representing the word spine in the disease’s name. SMA is intramuscular because it primarily affects muscles that do not receive signals from these neurons. Atrophy is the medical term for contraction, which generally happens to muscles when nerve cells are no longer stimulated.
Spinal muscular atrophy, a motor neuron disease, is characterized by the loss of nerve cells termed motor neurons in the spinal cord.
In terms of age of start, kind of symptoms, and pace of development, the most prevalent form of SMA (chromosome 5 SMA or SMN-associated SMA) is quite variable. SMA linked to chromosome 5 is often genetically recessive and is divided into categories 1 through 4 to account for these variations.
The age at which SMA symptoms first appear and the degree to which motor function is impacted are closely correlated; the earlier the period at which symptoms first appear, the more significant the impact on motor function. The lowest degree of functioning (type 1) is typically evident in children who exhibit symptoms at birth or during infancy. SMA types 2 and 3, as well as type 4 in adults or adolescents, which start later and have a less severe outcome, are typically linked to
What Causes Spinal Muscular Atrophy?
Mutations in genes other than SMN1.3 cause other rare forms of SMA (other than chromosome 5)
Signs and Symptoms of Spinal Muscular Atrophy
Symptoms of spinal muscular atrophy vary and may be mild or disabling but involve muscle weakness that controls movement. Involuntary muscles, such as the heart, blood vessels, and digestive system, are unaffected.
SMA weakens the muscles closest to the body’s center, including the shoulders, hips, thighs, and upper back. The affected child may develop a curvature of the spine (scoliosis) due to a loss of volume and strength of the back muscles.
The development of spinal muscular atrophy can also affect breathing and swallowing, which can be life-threatening for the patient.
What is the Evolution of the Spinal Muscular Atrophy?
In SMA linked to chromosome 5, the later the symptoms begin, and the higher the SMN protein, the milder the disease course is likely to be. Whereas children with mild muscular dystrophy did not live longer than two years in the past, most clinicians today consider SMN-related spinal muscular atrophy as a continuum and prefer not to make strict predictions about life expectancy or vulnerability based on the age of onset. SMA is the most common genetic cause of death in infants.
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